rs33951465
A SNP in the HBB gene on chromosome 11. Its most notable genotype is A;T: Carrier of a hemoglobin beta-thalassemia mutation
- Gene
- HBB
- Location
- Chr 115,226,947 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- A;TMost notableBadCarrier of a hemoglobin beta-thalassemia mutation
- A;AGoodcommon in complete genomics
- TG;TGGoodcommon in clinvar
SNPedia records rs33951465 on the minus strand: (A;T), (T;T), (TG;TG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other HBB SNPs
- rs11549407A;ABeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33945777T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33960103G;GBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33971440T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs33974936T;TBeta Thalassemia major; Hemoglobin beta-zeroVery important
- rs33986703A;ABeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34716011T;TBeta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
- rs34889882-;-Beta Thalassemia major; Hemoglobin beta-zero; possibly transfusion dependentVery important
Notes
From SNPedia
Notes
aka c.75T>A (p.Gly25=); OMIM notes that the 1983 publication reporting this mutation indicated it affects mRNA rather than the protein FTDNA & MyHeritage name: VG11S5372
Source and license
Adapted from rs33951465 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.