rs35572355
A SNP in the CDH1 gene on chromosome 16. Its most notable genotype is A;G: Possibly pathogenic for hereditary cancer-predisposing syndrome, but note lack of consensus
- Gene
- CDH1
- Location
- Chr 1668,833,344 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadPossibly pathogenic for hereditary cancer-predisposing syndrome, but note lack of consensus
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CDH1 SNPs
- rs121964873G;TCDH1-based gastric cancer riskVery important
- rs121964874C;TCDH1-based gastric cancer riskVery important
- rs121964876G;TFalse positives possible; otherwise, Hereditary cancer-predisposing syndromeVery important
- rs121964877C;TCDH1-based gastric cancer riskVery important
- rs267606712A;GCDH1-based gastric cancer riskVery important
- rs587776398G;TCDH1-based gastric cancer riskVery important
- rs587780113A;GCDH1-based gastric cancer riskVery important
- rs587780784C;TCDH1-based gastric cancer riskVery important
Notes
From SNPedia
Notes
aka c.2494G>A (p.Val832Met) Note that different clinical labs have come to different conclusions about the pathogenicity of this variant. As summarized in this blog post, classifications from eight different labs varied from benign (1 lab) to pathogenic (3 labs) with other labs designating it's clinical significance as uncertain.
A;G
See text on main rs-page regarding lack of consensus between clinical labs about the pathogenicity of this genotype.
Source and license
Adapted from rs35572355 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.