rs3738401

A SNP in the TSNAX-DISC1 gene on chromosome 1. Its most notable genotype is A;A.

Gene
TSNAX-DISC1
Location
Chr 1231,694,549 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Worth knowing · 2.06% of people
  2. G;GGoodcommon in clinvarTypical · 0.058% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 6% G;G 58%
  • European ancestry (Utah)A;A 15% G;G 43%
  • Han Chinese (Beijing)A;A 4% G;G 60%
  • Japanese (Tokyo)A;A 5% G;G 46%
  • Yoruba (Nigeria)A;A 0% G;G 84%
  • African ancestry (Southwest US)A;A 9% G;G 56%
  • Chinese (Denver)A;A 6% G;G 55%
  • Gujarati IndianA;A 5% G;G 63%
  • Luhya (Kenya)A;A 2% G;G 81%
  • Mexican ancestry (Los Angeles)A;A 10% G;G 35%
  • Maasai (Kenya)A;A 3% G;G 71%
  • TuscanA;A 10% G;G 46%

Conditions, medicines and genes

Other TSNAX-DISC1 SNPs

All TSNAX-DISC1 SNPs

Notes

From SNPedia

Notes

rs3738401 is a SNP in the DISC1 gene, known as R264Q. Associated with schizophrenia 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families. *rs751229(T) and rs3738401(A) was over-transmitted to males with psychotic disorder. *under-transmitted rs821616(T) and rs1411771(T) *The risk haplotype for psychotic disorder also associated to perseverations (P = 0.035; for rs751229 alone P = 0.0012), and a protective haplotype G-T-G with rs1655285 in addition to auditory attention (P = 0.0059).

A;A

rs3738401(A;A) and rs751229(G;G) together indicate homozygosity for the HEP3 haplotype of DISC1.

Source and license

Adapted from rs3738401 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.