rs821616

A SNP in the TSNAX-DISC1 gene on chromosome 1. Its most notable genotype is T;T: cognitive decline in older women

Gene
TSNAX-DISC1
Location
Chr 1232,008,852 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
25%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedcognitive decline in older womenTypical · 0.07% of people
  2. A;TNot rated?Typical · 0.032% of people
  3. A;ANot ratednormalTypical · 0.061% of people

SNPedia records rs821616 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 7% A;T 32% A;A 61%
  • European ancestry (Utah)T;T 14% A;T 39% A;A 48%
  • Han Chinese (Beijing)T;T 2% A;T 24% A;A 73%
  • Japanese (Tokyo)T;T 2% A;T 9% A;A 89%
  • Yoruba (Nigeria)T;T 11% A;T 56% A;A 33%

Conditions, medicines and genes

Other TSNAX-DISC1 SNPs

All TSNAX-DISC1 SNPs

Notes

From SNPedia

Notes

Women with two rs821616(T) SNPs seem to experience more rapid cognitive decline as they age compared to men. 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families. *rs821616 verbal fluency

Source and license

Adapted from rs821616 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.