rs3740066
A SNP in the ABCC2 gene on chromosome 10. Its most notable genotype is T;T: 4.4x risk for ICP
- Gene
- ABCC2
- Location
- Chr 1099,844,450 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 30%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBad4.4x risk for ICP
- C;TBad1.6x risk for ICP
- G;GNot ratedNo summary available.
- C;CGoodaverage
SNPedia records rs3740066 on the minus strand: (A;A), (A;G), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 7% C;T 44% G;G 0% C;C 49%
- European ancestry (Utah)T;T 8% C;T 51% G;G 0% C;C 42%
- Han Chinese (Beijing)T;T 4% C;T 44% G;G 0% C;C 51%
- Japanese (Tokyo)T;T 9% C;T 39% G;G 0% C;C 52%
- Yoruba (Nigeria)T;T 8% C;T 43% G;G 0% C;C 49%
Related
Conditions, medicines and genes
Other ABCC2 SNPs
- rs2273697A;AAdverse reaction more likely to carbamazepine in epileptic patientsMinor
- rs717620C;Ccommon in clinvarTypical
- rs927344T;Tcommon in complete genomicsTypical
- rs3740071G;Gcommon genotypeTypical
- rs8187710G;Gcommon on affy axiom dataTypical
- rs17222547C;Ccommon in clinvarTypical
- rs17222723T;Tcommon on affy axiom dataTypical
Notes
From SNPedia
Notes
rs3740066, a SNP in the ABCC2 gene, is reported to be associated with a higher risk of developing intrahepatic cholestasis of pregnancy (ICP) based on a study of ~70 Argentinian patients. ICP is associated with increased fetal risks such as premature birth or intrauterine death. The risk allele is rs3740066(A), and the odds ratio for homozygous rs3740066(A;A) mothers is 4.44 (CI: 1.83 - 10.78), and for heterozygous mothers 1.65 (CI: 0.76 - 3.64), compared to rs3740066(G;G) mothers.
C;C
Less likely to have intrahepatic cholestasis of pregnancy.
Source and license
Adapted from rs3740066 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.