rs717620

A SNP in the ABCC2 gene on chromosome 10. Its most notable genotype is C;C: common in clinvar

Gene
ABCC2
Location
Chr 1099,782,821 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.076% of people

SNPedia records rs717620 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 76%
  • European ancestry (Utah)C;C 65%
  • Han Chinese (Beijing)C;C 64%
  • Japanese (Tokyo)C;C 65%
  • Yoruba (Nigeria)C;C 94%
  • African ancestry (Southwest US)C;C 93%
  • Chinese (Denver)C;C 66%
  • Gujarati IndianC;C 86%
  • Luhya (Kenya)C;C 95%
  • Mexican ancestry (Los Angeles)C;C 57%
  • Maasai (Kenya)C;C 90%
  • TuscanC;C 64%

Other ABCC2 SNPs

All ABCC2 SNPs

Notes

From SNPedia

Show notes, about 140 words

Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease. MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer. Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients. ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir. Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry. A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis.

Source and license

Adapted from rs717620 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.