rs3740878

A SNP in the EXT2 gene on chromosome 11. Its most notable genotype is T;T: 1.46x type II diabetes risk; common

Gene
EXT2
Location
Chr 1144,236,252 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.46x type II diabetes risk; commonMinor · 1.258% of people
  2. C;TBad1.26x type II diabetes riskMinor · 1.132% of people

SNPedia records rs3740878 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 58% C;T 32%
  • European ancestry (Utah)T;T 56% C;T 32%
  • Han Chinese (Beijing)T;T 40% C;T 40%
  • Japanese (Tokyo)T;T 42% C;T 42%
  • Yoruba (Nigeria)T;T 84% C;T 14%
  • African ancestry (Southwest US)T;T 74% C;T 25%
  • Chinese (Denver)T;T 28% C;T 53%
  • Gujarati IndianT;T 43% C;T 42%
  • Luhya (Kenya)T;T 93% C;T 7%
  • Mexican ancestry (Los Angeles)T;T 29% C;T 48%
  • Maasai (Kenya)T;T 86% C;T 14%
  • TuscanT;T 61% C;T 32%

Other EXT2 SNPs

All EXT2 SNPs

Notes

From SNPedia

Notes

rs3740878 increases susceptibility to Type II Diabetes 1.26 times for heterozygotes (AG) and 1.46 times for homozygotes (AA)

Source and license

Adapted from rs3740878 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.