rs3754777

A SNP in the STK39 gene on chromosome 2. Its most notable genotype is T;T: slightly higher blood pressure if Caucasian

Gene
STK39
Location
Chr 2168,159,404 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadslightly higher blood pressure if CaucasianMinor · 1.54% of people
  2. C;TBadslightly higher blood pressure if CaucasianTypical · 0.030% of people
  3. C;CGoodnormalTypical · 0.066% of people

SNPedia records rs3754777 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 4% C;T 30% C;C 66%
  • European ancestry (Utah)T;T 5% C;T 21% C;C 74%
  • Han Chinese (Beijing)T;T 7% C;T 45% C;C 48%
  • Japanese (Tokyo)T;T 4% C;T 31% C;C 65%
  • Yoruba (Nigeria)T;T <1% C;T 22% C;C 77%
  • African ancestry (Southwest US)T;T 5% C;T 26% C;C 68%
  • Chinese (Denver)T;T 7% C;T 41% C;C 53%
  • Gujarati IndianT;T 9% C;T 28% C;C 63%
  • Luhya (Kenya)T;T 0% C;T 16% C;C 85%
  • Mexican ancestry (Los Angeles)T;T 5% C;T 44% C;C 51%
  • Maasai (Kenya)T;T <1% C;T 21% C;C 79%
  • TuscanT;T 5% C;T 32% C;C 63%

Other STK39 SNPs

All STK39 SNPs

Notes

From SNPedia

Notes

rs3754777 is a SNP in the serine threonine kinase 39 STK39 gene. A study of ~1,000 Amish originally identified rs3754777 and another SNP also in the STK39 gene, rs6749447, as being significantly associated with hypertension. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case rs3754777(A), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure. High Blood Pressure (Hypertension)

Source and license

Adapted from rs3754777 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.