rs6749447
A SNP in the STK39 gene on chromosome 2. Its most notable genotype is G;G: slightly higher blood pressure if Caucasian
- Gene
- STK39
- Location
- Chr 2168,184,876 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 46%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableBadslightly higher blood pressure if Caucasian
- G;TNot ratedslightly higher blood pressure if Caucasian
- T;TNot ratednormal
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 35% G;T 45% T;T 20%
- European ancestry (Utah)G;G 5% G;T 48% T;T 48%
- Han Chinese (Beijing)G;G 53% G;T 36% T;T 11%
- Japanese (Tokyo)G;G 52% G;T 39% T;T 9%
- Yoruba (Nigeria)G;G 30% G;T 59% T;T 11%
Related
Notes
From SNPedia
Notes
rs6749447 is a SNP in the serine threonine kinase 39 STK39 gene. A study of ~1,000 Amish originally identified rs6749447 and another SNP also in the STK39 gene, rs3754777, as being significantly associated with hypertension. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case rs6749447(G), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure.
Source and license
Adapted from rs6749447 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.