rs3775948

A SNP in the LOC105374476 gene on chromosome 4. Its most notable genotype is C;C: slightly higher risk for gout

Gene
LOC105374476
Location
Chr 49,993,558 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodslightly lower risk for goutMinor · 1.611% of people
  2. C;GBadslightly higher risk for goutMinor · 1.649% of people
  3. C;CMost notableBadslightly higher risk for goutWorth knowing · 2.040% of people

SNPedia records rs3775948 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 11% C;G 49% C;C 40%
  • European ancestry (Utah)G;G 8% C;G 48% C;C 45%
  • Han Chinese (Beijing)G;G 13% C;G 58% C;C 29%
  • Japanese (Tokyo)G;G 11% C;G 51% C;C 38%
  • Yoruba (Nigeria)G;G 11% C;G 40% C;C 49%

Conditions, medicines and genes

Other LOC105374476 SNPs

All LOC105374476 SNPs

Notes

From SNPedia

Notes

gout association, based on note that due to the possibility of ambiguous flipping between the C/G alleles of this SNP, care should be taken in interpreting alleles

Source and license

Adapted from rs3775948 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.