rs6449213

A SNP in the LOC105374476 gene on chromosome 4. Its most notable genotype is C;C: ~4x higher risk for hyperuracemia

Gene
LOC105374476
Location
Chr 49,992,591 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
13%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad~4x higher risk for hyperuracemiaWorth knowing · 2.01% of people
  2. C;TBad~2x higher risk for hyperuracemiaTypical · 0.022% of people
  3. T;TGoodnormalTypical · 0.077% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 1% C;T 22% T;T 77%
  • European ancestry (Utah)C;C 2% C;T 35% T;T 64%
  • Han Chinese (Beijing)C;C 0% C;T 4% T;T 96%
  • Japanese (Tokyo)C;C 0% C;T 2% T;T 98%
  • Yoruba (Nigeria)C;C 1% C;T 22% T;T 76%
  • African ancestry (Southwest US)C;C 0% C;T 30% T;T 70%
  • Chinese (Denver)C;C 0% C;T 9% T;T 91%
  • Gujarati IndianC;C 0% C;T 30% T;T 70%
  • Luhya (Kenya)C;C 0% C;T 21% T;T 79%
  • Mexican ancestry (Los Angeles)C;C 5% C;T 29% T;T 66%
  • Maasai (Kenya)C;C 1% C;T 30% T;T 69%
  • TuscanC;C 3% C;T 28% T;T 70%

Other LOC105374476 SNPs

All LOC105374476 SNPs

Notes

From SNPedia

Notes

This is basically a surrogate for rs7442295, and thus associated with higher serum urate levels.

Source and license

Adapted from rs6449213 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.