rs377713277

A SNP. Its most notable genotype is C;T: Possibly increased breast cancer risk, but see discussion

Gene
None listed
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableBadPossibly increased breast cancer risk, but see discussionWorth knowing · 2.2

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.3128G>A (p.Gly1043Asp or G1043D) This missense variant in the PALB2 gene is reported based on a functional assay published in 2019 to significantly reduce DNA repair efficiency, and thereby to *potentially* significantly increase breast cancer risk. However, the extent of increased risk is unknown.

C;T

see discussion and links via main rs-page

Source and license

Adapted from rs377713277 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.