rs381737
A SNP in the GBA gene on chromosome 1. Its most notable genotype is T;T: Gaucher disease (predicted if orientation is correct)
- Gene
- GBA
- Location
- Chr 1155,238,141 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadGaucher disease (predicted if orientation is correct)
- A;TBadUnaffected carrier of Gaucher disease variant
- A;AGoodcommon in clinvar
SNPedia records rs381737 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other GBA SNPs
- rs1064651G;Gpossibly Gaucher's disease, but more likely a mis-oriented interpretationVery important
- rs387906315C;CGaucher diseaseVery important
- rs104886460A;AGaucher diseaseVery important
- i4000415C;CGaucher's diseaseVery important
- i4000417G;GGaucher's diseaseVery important
- i4000419A;AGaucher's diseaseVery important
- rs76763715C;CGaucher's disease, type 1Very important
- i4000386T;TGaucher's diseaseVery important
Notes
From SNPedia
Notes
T;T
see rs381737; be wary of ambiguous flip and orientation issues
A;T
see rs381737
Source and license
Adapted from rs381737 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.