rs3825942(A;A)

10x to 27x lower risk of exfoliation glaucoma

Magnitude
2.5Worth knowing
Repute
Good
Frequency
7%Average of 11 populations
On SNPedia
rs3825942(A;A)
Gene
LOXL1

Frequency

Share of people with A;A in each HapMap population.

  • Luhya (Kenya)19%
  • African ancestry (Southwest US)18%
  • Yoruba (Nigeria)15%
  • Maasai (Kenya)13%
  • Gujarati Indian6%
  • Mexican ancestry (Los Angeles)4%
  • Japanese (Tokyo)2%
  • Tuscan2%
  • Han Chinese (Beijing)2%
  • Chinese (Denver)1%
  • European ancestry (Utah)0%

Other genotypes of rs3825942

  1. A;GGoodpossibly lower glaucoma riskMinor · 1.836% of people
  2. G;GBadcommon but 10x higher glaucoma risk in most (but not all) populationsWorth knowing · 2.357% of people

All about rs3825942

Notes

From SNPedia

Unless you are a black south African, this uncommon SNP drastically reduces your risk of exfoliation glaucoma (also known as exfoliation syndrome, or pseudoexfoliation syndrome PEX). That form of glaucoma causes up to 10% of the cases of blindness in many countries, including the US. This mutation may not protect you from other kinds of glaucoma though.

References

Source and license

Adapted from rs3825942(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.