rs3850641

(2016 article) "An association between GG genotype of rs3850641 in TNFSF4 gene and AITDs was found (p = 0.046). Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age. Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto’s thyroiditis (HT) (p = 0.018)." (Abstract). ... "Further analysis found that the frequencies of TT genotype in rs7514229 and GG genotype in rs3850641 were lower in the AITDs group than the control group (Table 3), which suggested that people with these genotypes are less susceptible to AITDs (p = 0.016, OR = 0.236, 95% CI = 0.066–0.850 and p = 0.027, OR = 0.492, 95% CI = 0.259–0.935, respectively)." . Participants were genotyped for the rs3850641 SNP in TNFSF4. Genotype associations were neither found with TNFSF4 mRNA levels nor with atherosclerosis associated systemic factors or risk for stroke. (2005 article). "In two independent human populations, the less common allele of SNP rs3850641 in TNFSF4 was significantly more frequent (P <or= 0.05) in individuals with myocardial infarction than in controls." (Abstract) (2011 article) "The rs45454293T-allele, in agreement with the linked rs3850641G-allele, proved to be associated with increased risk of MI in women."