rs7514229

A SNP in the TNFSF4 gene on chromosome 1. Its most notable genotype is T;T: Less susceptible to autoimmune thyroid diseases

Gene
TNFSF4
Location
Chr 1173,185,165 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GBadassociated with early-onset autoimmune thyroid diseaseMinor · 1.242% of people
  2. T;TMost notableGoodLess susceptible to autoimmune thyroid diseasesMinor · 1.519% of people

On SNPedia: (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 42% T;T 19%
  • European ancestry (Utah)G;G 47% T;T 8%
  • Han Chinese (Beijing)G;G 78% T;T 2%
  • Japanese (Tokyo)G;G 87% T;T <1%
  • Yoruba (Nigeria)G;G 8% T;T 54%
  • African ancestry (Southwest US)G;G 5% T;T 44%
  • Chinese (Denver)G;G 81% T;T <1%
  • Gujarati IndianG;G 48% T;T 7%
  • Luhya (Kenya)G;G 10% T;T 46%
  • Mexican ancestry (Los Angeles)G;G 43% T;T 5%
  • Maasai (Kenya)G;G 17% T;T 31%
  • TuscanG;G 39% T;T 14%

Other TNFSF4 SNPs

All TNFSF4 SNPs

Notes

From SNPedia

Show notes, about 130 words

. (2016 article) "An association between GG genotype of rs3850641 in TNFSF4 gene and AITDs was found (p = 0.046). Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age. Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto’s thyroiditis (HT) (p = 0.018)." (Abstract). ... "Further analysis found that the frequencies of TT genotype in rs7514229 and GG genotype in rs3850641 were lower in the AITDs group than the control group (Table 3), which suggested that people with these genotypes are less susceptible to AITDs (p = 0.016, OR = 0.236, 95% CI = 0.066–0.850 and p = 0.027, OR = 0.492, 95% CI = 0.259–0.935, respectively)."

Source and license

Adapted from rs7514229 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.