rs3865418

A SNP in the NEDD4L gene on chromosome 18. Its most notable genotype is C;C: normal

Gene
NEDD4L
Location
Chr 1858,336,932 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.028% of people
  2. C;TNot rated1.3x increased risk for hypertensionTypical · 0.045% of people
  3. G;GNot ratedNo summary available.Typical · 0.00% of people
  4. T;TNot rated>1.3x increased risk for hypertensionTypical · 0.027% of people

On SNPedia: (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 28% C;T 45% G;G 0% T;T 27%
  • European ancestry (Utah)C;C 30% C;T 42% G;G 0% T;T 29%
  • Han Chinese (Beijing)C;C 39% C;T 50% G;G 0% T;T 12%
  • Japanese (Tokyo)C;C 50% C;T 43% G;G 0% T;T 7%
  • Yoruba (Nigeria)C;C 14% C;T 44% G;G 0% T;T 42%
  • African ancestry (Southwest US)C;C 25% C;T 46% G;G 0% T;T 30%
  • Chinese (Denver)C;C 46% C;T 44% G;G 0% T;T 10%
  • Gujarati IndianC;C 32% C;T 42% G;G 0% T;T 27%
  • Luhya (Kenya)C;C 13% C;T 42% G;G 0% T;T 46%
  • Mexican ancestry (Los Angeles)C;C 28% C;T 57% G;G 0% T;T 16%
  • Maasai (Kenya)C;C 12% C;T 46% G;G 0% T;T 42%
  • TuscanC;C 19% C;T 42% G;G 0% T;T 39%

Other NEDD4L SNPs

All NEDD4L SNPs

Notes

From SNPedia

Notes

rs3865418, a SNP in the NEDD4L gene, has been associated with hypertension in a study of Chinese (Hans) patients. Association under an additive model yielded an odds ratio of 1.31 (CI: 1.04-1.67, p=0.025) for the rs3865418(T) allele. The association remained significant (p = 0.039) after adjusting for age and sex, and was primarily associated with significantly higher diastolic blood pressure.

Source and license

Adapted from rs3865418 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.