rs4149601

A SNP in the NEDD4L gene on chromosome 18. Its most notable genotype is G;G: common in clinvar

Gene
NEDD4L
Location
Chr 1858,149,559 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.052% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 52%
  • European ancestry (Utah)G;G 39%
  • Han Chinese (Beijing)G;G 64%
  • Japanese (Tokyo)G;G 80%
  • Yoruba (Nigeria)G;G 38%
  • African ancestry (Southwest US)G;G 54%
  • Chinese (Denver)G;G 64%
  • Gujarati IndianG;G 61%
  • Luhya (Kenya)G;G 27%
  • Mexican ancestry (Los Angeles)G;G 78%
  • Maasai (Kenya)G;G 21%
  • TuscanG;G 43%

Other NEDD4L SNPs

All NEDD4L SNPs

Notes

From SNPedia

Show notes, about 230 words

rs4149601 has been associated with hypertension. This SNP by itself was associated with diastolic blood pressure (DBP) (p=0.03) and DBP progression over time (p=0.04); in genotypic combination with intronic NEDD4L SNP rs2288774 it was associated with systolic blood pressure (SBP) (p=0.01), DBP (p=0.04), and progression of both SBP (p=0.03) and DBP (p=0.05) over time. Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP. Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension. Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study. Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation. Suggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch population. A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study. Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain. [Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population].

Source and license

Adapted from rs4149601 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.