rs387906650
A SNP in the MAX gene on chromosome 14. Its most notable genotype is A;G: Hereditary PGL/PCC Syndrome
- Gene
- MAX
- Location
- Chr 1465,077,985 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon genotype
- A;GMost notableBadHereditary PGL/PCC Syndrome
SNPedia records rs387906650 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MAX SNPs
- rs786203009A;THereditary PGL/PCC SyndromeVery important
- rs786203385C;THereditary PGL/PCC SyndromeVery important
- rs876659610A;THereditary PGL/PCC SyndromeVery important
- rs876660073G;THereditary PGL/PCC SyndromeVery important
- rs1957948C;Ccommon in clinvarTypical
- rs1957949C;Ccommon in clinvarTypical
- rs4902359G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
aka c.223C>T (p.Arg75Ter or R75X) ClinVar and agree that this mutation is predisposing for a hereditary cancer (paraganglioma-pheochromocytoma) syndrome
Source and license
Adapted from rs387906650 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.