rs3889728
A SNP in the AGT gene on chromosome 1. Its most notable genotype is T;T: increased risk for preeclampsia
- Gene
- AGT
- Location
- Chr 1230,713,085 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 31%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot ratedincreased risk for preeclampsia
- C;TNot ratedincreased risk for preeclamppsia
- C;CNot ratednormal risk
SNPedia records rs3889728 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 14% C;T 33% C;C 53%
- European ancestry (Utah)T;T 2% C;T 22% C;C 76%
- Han Chinese (Beijing)T;T 24% C;T 40% C;C 37%
- Japanese (Tokyo)T;T 33% C;T 50% C;C 18%
- Yoruba (Nigeria)T;T 0% C;T 19% C;C 81%
Related
Conditions, medicines and genes
Other AGT SNPs
- rs74315283C;TCarrier for a renal tubular dysgenesis mutationImportant
- rs121912702A;GCarrier for a renal tubular dysgenesis mutationImportant
- rs387906578-;ACarrier for a renal tubular dysgenesis mutationImportant
- rs699G;Gincreased risk of hypertensionWorth knowing
- rs4762G;Gnormal riskTypical
- rs5050T;Tcommon in clinvarTypical
- rs5051C;Cnormal riskTypical
- rs7079G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
rs3889728 is a SNP in the AGT gene that, at least when part of a haplotype, has been associated with increased risk for developing pre-eclampsia, but it was not reported to have the most influence of the 3 SNPs in the haplotype. The 2.1 fold increased risk (CI: 1.4-3.4, p=0.0008) for pre-eclampsia was reported for haplotype rs3889728(A)-rs4762(T)-rs699(C).
Source and license
Adapted from rs3889728 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.