rs3914132

A SNP in the RELN gene on chromosome 7. Its most notable genotype is C;C: Lower otosclerosis risk

Gene
RELN
Location
Chr 7103,886,922 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodLower otosclerosis riskWorth knowing · 2.04% of people
  2. C;TGoodLower otosclerosis riskWorth knowing · 2.028% of people
  3. T;TNot ratedNormal (not lower) otosclerosis riskMinor · 1.068% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 4% C;T 28% T;T 68%
  • European ancestry (Utah)C;C 6% C;T 26% T;T 68%
  • Han Chinese (Beijing)C;C 2% C;T 11% T;T 87%
  • Japanese (Tokyo)C;C 3% C;T 15% T;T 82%
  • Yoruba (Nigeria)C;C 5% C;T 37% T;T 59%
  • African ancestry (Southwest US)C;C 4% C;T 30% T;T 66%
  • Chinese (Denver)C;C 0% C;T 24% T;T 76%
  • Gujarati IndianC;C 7% C;T 30% T;T 63%
  • Luhya (Kenya)C;C 4% C;T 32% T;T 64%
  • Mexican ancestry (Los Angeles)C;C 5% C;T 36% T;T 59%
  • Maasai (Kenya)C;C 4% C;T 30% T;T 66%
  • TuscanC;C 2% C;T 39% T;T 59%

Conditions, medicines and genes

Other RELN SNPs

All RELN SNPs

Notes

From SNPedia

Notes

Each C allele at rs3914132 decreases the likelihood of developing otosclerosis, which can cause hearing loss.

Source and license

Adapted from rs3914132 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.