rs7341475

A SNP in the RELN gene on chromosome 7. Its most notable genotype is G;G: 1.58x increased schizophrenia risk for women

Gene
RELN
Location
Chr 7103,764,368 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.02% of people
  2. A;GNot ratednormalTypical · 0.025% of people
  3. G;GMost notableBad1.58x increased schizophrenia risk for womenMinor · 1.572% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 2% A;G 25% G;G 72%
  • European ancestry (Utah)A;A 3% A;G 23% G;G 74%
  • Han Chinese (Beijing)A;A 0% A;G 20% G;G 80%
  • Japanese (Tokyo)A;A 3% A;G 20% G;G 77%
  • Yoruba (Nigeria)A;A <1% A;G 32% G;G 67%
  • African ancestry (Southwest US)A;A 0% A;G 19% G;G 81%
  • Chinese (Denver)A;A 0% A;G 10% G;G 90%
  • Gujarati IndianA;A 2% A;G 27% G;G 71%
  • Luhya (Kenya)A;A 3% A;G 31% G;G 66%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 31% G;G 62%
  • Maasai (Kenya)A;A 5% A;G 37% G;G 59%
  • TuscanA;A 4% A;G 28% G;G 68%

Conditions, medicines and genes

Other RELN SNPs

All RELN SNPs

Notes

From SNPedia

Notes

A total of 2,274 cases of schizophrenia were studied, resulting in an association between rs7341475, exclusively in women. Based on all populations the estimated relative risk for women carrying the common (G;G) genotype is 1.58 (p = 8.8 x 10( -7 ). This finding was replicated in a large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female), with confirmation that it applies to both schizophrenia and schizoaffective disorder.

Source and license

Adapted from rs7341475 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.