rs397516830
A SNP in the RAF1 gene on chromosome 3. Its most notable genotype is A;C: Noonan syndrome
- Gene
- RAF1
- Location
- Chr 312,604,182 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- A;CMost notableBadNoonan syndrome
- A;AGoodcommon in clinvar
SNPedia records rs397516830 on the minus strand: (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other RAF1 SNPs
- rs3730271A;TNoonan syndromeVery important
- rs80338796A;GNoonan syndromeVery important
- rs80338797C;GNoonan syndromeVery important
- rs80338799C;GNoonan syndromeVery important
- rs121434594A;GNoonan syndromeVery important
- rs397516813C;GNoonan syndromeVery important
- rs397516826C;GNoonan syndromeVery important
- rs727505017A;GNoonan syndromeVery important
Notes
From SNPedia
Notes
aka c.788T>G (p.Val263Gly)
A;C
see links via main rs-page
Source and license
Adapted from rs397516830 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.