rs397517159

A SNP in the SOS1 gene on chromosome 2. Its most notable genotype is C;T: Noonan syndrome

Gene
SOS1
Location
Chr 239,007,168 (GRCh38)
Highest magnitude
7.0Very important
Tested on
23andMe

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableBadNoonan syndromeVery important · 7.0
  2. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs397517159 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SOS1 SNPs

All SOS1 SNPs

Notes

From SNPedia

Notes

aka c.2536G>A (p.Glu846Lys)

C;T

see links via main rs-page

Source and license

Adapted from rs397517159 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.