rs398122403

A SNP in the SYNJ1 gene on chromosome 21. Its most notable genotype is T;T: Parkinson disease, early-onset, type 20

Gene
SYNJ1
Location
Chr 2132,695,106 (GRCh38)
Highest magnitude
7.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadParkinson disease, early-onset, type 20Very important · 7.0
  2. C;TBadCarrier of a Parkinson disease mutationImportant · 3.0
  3. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs398122403 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

aka c.773G>A (p.Arg258Gln or R258Q) Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal recessive, early-onset Parkinson disease (type 20) See also OMIM 604297.0001

T;T

See text and links via main rs-page

C;T

Unaffected in absence of a second mutation in the SYNJ1 gene

Source and license

Adapted from rs398122403 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.