rs398122418
A SNP in the MAGEL2 gene on chromosome 15. Its most notable genotype is A;G: Prader-Willi-like syndrome; Schaaf-Yang syndrome
- Gene
- MAGEL2
- Location
- Chr 1523,644,619 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadPrader-Willi-like syndrome; Schaaf-Yang syndrome
SNPedia records rs398122418 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MAGEL2 SNPs
- rs398122415-;APrader-Willi-like syndrome; Schaaf-Yang syndromeVery important
- rs398122416-;GPrader-Willi-like syndrome; Schaaf-Yang syndromeVery important
- rs398122417-;ATPrader-Willi-like syndrome; Schaaf-Yang syndromeVery important
- rs770374710-;GPossible miscall in Ancestry v2c data; otherwise, Prader-Willi-like syndrome; Schaaf-Yang syndromeVery important
Notes
From SNPedia
Notes
aka c.3124C>T, p.Gln1042Ter, Q1024X or Q1024*
A;G
see discussion at MAGEL2
Source and license
Adapted from rs398122418 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.