rs398123063

A SNP in the LOC105376032 gene on chromosome 9. Its most notable genotype is T;T: increased risk for pre-B cell acute lymphoblastic leukemia (B-ALL)

Gene
LOC105376032
Location
Chr 937,002,705 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadincreased risk for pre-B cell acute lymphoblastic leukemia (B-ALL)Important · 3.0
  2. C;TBadassociated with increased risk for pre-B cell acute lymphoblastic leukemia (B-ALL)Important · 3.0
  3. C;CNot ratedcommon/normalTypical · 0.0

SNPedia records rs398123063 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs398123063(A), a rare variation known as c.547G>A or Gly183Ser, has been associated with autosomal dominant B cell precursor acute lymphoblastic leukemia (B-ALL). Individuals carrying this variation appear to require the deletion or inactivation of their normal allele at this locus to develop clinical symptoms of B-ALL.

Source and license

Adapted from rs398123063 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.