rs41309766

A SNP in the NOTCH1 gene on chromosome 9. Its most notable genotype is -;G: Possibly pathogenic for an aortic valve disorder

Gene
NOTCH1
Location
Chr 9136,505,384 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. -;GMost notableBadPossibly pathogenic for an aortic valve disorderVery important · 4.0
  2. G;GGoodcommon in clinvarTypical · 0.0

SNPedia records rs41309766 on the minus strand: (-;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other NOTCH1 SNPs

All NOTCH1 SNPs

Notes

From SNPedia

Notes

c.4512delC (p.Cys1505Valfs)

-;G

see ClinVar links via rs41309766 page

Source and license

Adapted from rs41309766 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.