rs419598

A SNP in the IL1RN gene on chromosome 2. Its most notable genotype is C;C: 0.29x lower risk for periodontitis

Gene
IL1RN
Location
Chr 2113,129,630 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated0.29x lower risk for periodontitisTypical · 0.04% of people
  2. C;TNot rated0.29x lower risk for periodontitisTypical · 0.024% of people
  3. T;TGoodnormalTypical · 0.072% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 4% C;T 24% T;T 72%
  • European ancestry (Utah)C;C 6% C;T 47% T;T 47%
  • Han Chinese (Beijing)C;C 0% C;T 15% T;T 85%
  • Japanese (Tokyo)C;C 0% C;T 14% T;T 86%
  • Yoruba (Nigeria)C;C 0% C;T 4% T;T 96%
  • African ancestry (Southwest US)C;C 0% C;T 12% T;T 88%
  • Chinese (Denver)C;C 3% C;T 14% T;T 84%
  • Gujarati IndianC;C 17% C;T 43% T;T 41%
  • Luhya (Kenya)C;C 0% C;T 7% T;T 93%
  • Mexican ancestry (Los Angeles)C;C 10% C;T 53% T;T 36%
  • Maasai (Kenya)C;C 0% C;T 8% T;T 92%
  • TuscanC;C 3% C;T 51% T;T 46%

Conditions, medicines and genes

Other IL1RN SNPs

All IL1RN SNPs

Notes

From SNPedia

Show notes, about 160 words

May modulate other variations. Also known as the +2018T/C SNP. In a study of 113 Japanese patients with chronic periodontitis (CP), individuals with the rs419598(C) allele are at 0.29x lower CP risk (p = 0.016). IL1B -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote . SO what's this have to do with rs419598? Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006"). Radiographic severity of knee osteoarthritis is conditional on Interleukin 1 Receptor Antagonist gene variations

T;T

One report indicates that rs419598(T;T) carriers, if they are also IL1B -511 heterozygotes, have an increased chance of surviving a bout of bacterial meningitis PMID 11023482. The (T;T) genotype is the most common in all populations studied.

References

Source and license

Adapted from rs419598 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.