rs4253778
A SNP in the PPARA gene on chromosome 22. Its most notable genotype is G;G: common in complete genomics
- Gene
- PPARA
- Location
- Chr 2246,234,737 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 25%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageG;G 54%
- European ancestry (Utah)G;G 64%
- Han Chinese (Beijing)G;G 100%
- Japanese (Tokyo)G;G 100%
- Yoruba (Nigeria)G;G 3%
- African ancestry (Southwest US)G;G 14%
- Gujarati IndianG;G 94%
- Luhya (Kenya)G;G 6%
- Mexican ancestry (Los Angeles)G;G 81%
- Maasai (Kenya)G;G 25%
- TuscanG;G 51%
Related
Notes
From SNPedia
Show notes, about 120 words
Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-alpha gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Do PPARGC1A and PPARalpha polymorphisms influence sprint or endurance phenotypes? Variation in the PPARalpha gene in Polish rowers. Association of the peroxisome proliferator-activated receptor alpha gene L162V polymorphism with stage C heart failure.
Source and license
Adapted from rs4253778 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.