rs4253623

A SNP in the PPARA gene on chromosome 22. Its most notable genotype is A;A: normal

Gene
PPARA
Location
Chr 2246,154,203 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.082% of people
  2. A;GNot rated1.25x higher risk of nonfatal myocardial infarctionTypical · 0.016% of people
  3. G;GNot rated1.25x higher risk of nonfatal myocardial infarctionTypical · 0.01% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 82% A;G 16% G;G 1%
  • European ancestry (Utah)A;A 74% A;G 25% G;G <1%
  • Han Chinese (Beijing)A;A 75% A;G 23% G;G 2%
  • Japanese (Tokyo)A;A 77% A;G 22% G;G <1%
  • Yoruba (Nigeria)A;A 92% A;G 8% G;G 0%
  • African ancestry (Southwest US)A;A 97% A;G 4% G;G 0%
  • Chinese (Denver)A;A 79% A;G 20% G;G <1%
  • Gujarati IndianA;A 67% A;G 31% G;G 2%
  • Luhya (Kenya)A;A 98% A;G 2% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 71% A;G 26% G;G 3%
  • Maasai (Kenya)A;A 98% A;G 2% G;G 0%
  • TuscanA;A 78% A;G 18% G;G 4%

Conditions, medicines and genes

Other PPARA SNPs

All PPARA SNPs

Notes

From SNPedia

Notes

rs4253623(G) alleles are associated with a slightly higher risk of nonfatal myocardial infarction (odds ratio 1.25, CI: 1.08 - 1.46) in 848 patients composed of both postmenopausal women and hypertensive men/women.

Source and license

Adapted from rs4253623 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.