rs4295627

A SNP in the CCDC26 gene on chromosome 8. Its most notable genotype is G;G: 1.85x higher risk for glioma development

Gene
CCDC26
Location
Chr 8129,673,211 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.85x higher risk for glioma developmentMinor · 1.64% of people
  2. G;TBad1.36x higher risk for glioma developmentMinor · 1.331% of people
  3. T;TGoodNo summary available.Typical · 0.065% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 4% G;T 31% T;T 65%
  • European ancestry (Utah)G;G 3% G;T 20% T;T 77%
  • Han Chinese (Beijing)G;G 8% G;T 41% T;T 51%
  • Japanese (Tokyo)G;G 3% G;T 33% T;T 65%
  • Yoruba (Nigeria)G;G 0% G;T 24% T;T 76%
  • African ancestry (Southwest US)G;G 2% G;T 21% T;T 77%
  • Chinese (Denver)G;G 6% G;T 38% T;T 56%
  • Gujarati IndianG;G 3% G;T 37% T;T 60%
  • Luhya (Kenya)G;G 5% G;T 35% T;T 61%
  • Mexican ancestry (Los Angeles)G;G 3% G;T 36% T;T 60%
  • Maasai (Kenya)G;G 5% G;T 32% T;T 63%
  • TuscanG;G 3% G;T 30% T;T 67%

Conditions, medicines and genes

Other CCDC26 SNPs

All CCDC26 SNPs

Notes

From SNPedia

Notes

23andMe blog rs4295627 G 1.36 Glioma New insights into susceptibility to glioma. Distinct germ line polymorphisms underlie glioma morphologic heterogeneity. Genetic causes of glioma: new leads in the labyrinth.

Source and license

Adapted from rs4295627 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.