rs55705857
A SNP in the CCDC26 gene on chromosome 8. Its most notable genotype is A;G: 6x increased risk of glioma of IDH1/IDH2 subtype
- Gene
- CCDC26
- Location
- Chr 8129,633,446 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
- Minor allele frequency
- 3%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodnormal (lower risk of glioma)
- A;GMost notableBad6x increased risk of glioma of IDH1/IDH2 subtype
- G;GBad6x increased risk of glioma of IDH1/IDH2 subtype
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 190 words
rs55705857 is a SNP located in a relatively gene-poor area of chromosomal region 8q24.21, near other SNPs that have been associated with certain cancers (prostate and ovarian). A study by UCSF and Mayo Clinic researchers of over 1,600 glioblastoma patients concluded that carriers of a rs55705857(G) allele are at 5 - 6 fold higher risk for developing a glioma disease subtype categorized by harboring IDH1 or IDH2 (somatic) mutations (for example, with oligodendrogliomas, the odds ratio was 6.3, CI 4.6–8.8, p = 2.2 × 10e−28). These risk factors are among the highest ever reported for cancer-associated SNPs found in a SNP survey; nonetheless, keep in mind that glioblastomas are quite rare, with on average 2 - 3 people per 100,000 diagnosed per year, even with an allele frequency for rs55705857(G) of between 2 - 8%. See also: http://www.genengnews.com/gen-news-highlights/gene-variant-raises-brain-tumor-risk/81247234/
A;A
The normal safe version of this SNP, like almost all humans and other mammals. It has a much lower risk of the brain cancer glioma (particularly the IDH1 or IDH2 versions).
Source and license
Adapted from rs55705857 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.