rs4343

A SNP in the ACE gene on chromosome 17. Its most notable genotype is A;A: ACE I/I genotype

Gene
ACE
Location
Chr 1763,488,670 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedACE I/I genotypeWorth knowing · 2.047% of people
  2. A;GNot ratedACE I/D genotypeWorth knowing · 2.039% of people
  3. G;GNot ratedACE D/D genotypeWorth knowing · 2.014% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 47% A;G 39% G;G 14%
  • European ancestry (Utah)A;A 27% A;G 49% G;G 25%
  • Han Chinese (Beijing)A;A 53% A;G 39% G;G 8%
  • Japanese (Tokyo)A;A 33% A;G 51% G;G 16%
  • Yoruba (Nigeria)A;A 67% A;G 27% G;G 6%
  • African ancestry (Southwest US)A;A 61% A;G 33% G;G 5%
  • Chinese (Denver)A;A 41% A;G 50% G;G 9%
  • Gujarati IndianA;A 36% A;G 50% G;G 15%
  • Luhya (Kenya)A;A 81% A;G 18% G;G <1%
  • Mexican ancestry (Los Angeles)A;A 41% A;G 40% G;G 19%
  • Maasai (Kenya)A;A 68% A;G 29% G;G 3%
  • TuscanA;A 12% A;G 47% G;G 41%

Other ACE SNPs

All ACE SNPs

Notes

From SNPedia

Show notes, about 130 words

See ACE for a more complete description of the history of the ACI insertion/deletion (I/D) allele and various associations reported over the years. Perhaps the best documented correlation of a linked SNP to the presence or absence of the Alu insertion represented by the I/D ACE polymorphism is rs4343. More specifically: the rs4343(A) allele is associated with the ACE-I (insertion) allele, and the rs4343(G) allele is associated with the ACE-D allele. Another SNP in linkage disequilibrium with the ACE I/D polymorphism is rs4341., A haplotype of rs4311, rs4343, rs699 increases risk of diabetic nephropathy 4x.

A;A

See ACE and rs4343; I/I genotypes might possibly have better endurance vs strength

A;G

see discussion at ACE and rs4343

G;G

see ACE and rs4343; ACE D/D genotypes might have better strength vs endurance

Source and license

Adapted from rs4343 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.