rs4344

A SNP in the ACE gene on chromosome 17. Its most notable genotype is A;A: faster responder

Gene
ACE
Location
Chr 1763,489,363 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedfaster responderTypical · 0.026% of people
  2. A;GNot ratedslower responderTypical · 0.048% of people
  3. G;GGoodfaster responderTypical · 0.025% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 26% A;G 48% G;G 25%
  • European ancestry (Utah)A;A 27% A;G 47% G;G 27%
  • Han Chinese (Beijing)A;A 53% A;G 39% G;G 8%
  • Japanese (Tokyo)A;A 33% A;G 51% G;G 16%
  • Yoruba (Nigeria)A;A 15% A;G 50% G;G 35%
  • African ancestry (Southwest US)A;A 5% A;G 67% G;G 28%
  • Chinese (Denver)A;A 41% A;G 49% G;G 10%
  • Gujarati IndianA;A 35% A;G 51% G;G 15%
  • Luhya (Kenya)A;A 19% A;G 48% G;G 33%
  • Mexican ancestry (Los Angeles)A;A 41% A;G 35% G;G 24%
  • Maasai (Kenya)A;A 9% A;G 51% G;G 40%
  • TuscanA;A 12% A;G 44% G;G 44%

Conditions, medicines and genes

Other ACE SNPs

All ACE SNPs

Notes

From SNPedia

Notes

This SNP in the ACE gene, also known as G12269A, is reported to influence how quickly African Americans respond to the anti-hypertensive drug ramipril. rs4344(A;A) and rs4344(G;G) homozygotes are able to reach lower blood pressure levels upon treatment with ramipril sooner than rs4344(A;G) heterozygotes. The odds ratio reported for this study, comparing both homozygotes to heterozygotes, is 1.86 (CI: 1.32-3.23). Note that this SNP is in almost complete linkage disequilibrium with the insertion/deletion ACE gene SNP.

G;G

Faster responder to ACE inhibitor Ramipril Altace.

Source and license

Adapted from rs4344 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.