rs440446

rs440446 is a SNP in an intron of the apolipoprotein E APOE gene; it is also known as the IVS1+69 variant. In a study of ~1,000 Chinese patients with various biliary tract conditions, including cancer and gallstones, men carrying a rs440446(C) allele (in dbSNP orientation) had a 1.7x risk of gallstone disease [CI: 1.2-2.4], a 1.8x risk of gallbladder cancer (CI: 1.0-3.3), a 3.7x risk of bile duct cancer (CI: 2.0-7.0), and a 4x risk of ampullary cancer (CI: 1.4-12.4). Note: orientation relative to dbSNP entry is reversed as published. Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis. Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes. Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Gender differences in genetic risk profiles for cardiovascular disease. A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females. A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India. The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks.