rs445925(A;A)
APOE E2/E2 most likely; lower Alzheimer's risk
- Magnitude
- 4.0Very important
- Repute
- Good
- Frequency
- 3%Average of 11 populations
- On SNPedia
- rs445925(T;T)Minus strand
- Gene
- LOC100129500
Frequency
Share of people with A;A in each HapMap population.
- Luhya (Kenya)11%
- Maasai (Kenya)7%
- African ancestry (Southwest US)4%
- Yoruba (Nigeria)3%
- Gujarati Indian1%
- European ancestry (Utah)<1%
- Han Chinese (Beijing)<1%
- Japanese (Tokyo)0%
- Chinese (Denver)0%
- Mexican ancestry (Los Angeles)0%
- Tuscan0%
Other genotypes of rs445925
Notes
From SNPedia
Likely to have 2 copies of the ApoE2 allele, as long as rs7412 is not (C;C) or (C;T), and the lowest risk of Alzheimer's disease (among ApoE genotypes). Based on a statistical correlation in some populations; see discussion at rs445925. Presence of gs268 confirms E2/E2 status if present; most other ApoE genosets (such as gs270 or gs216) take precedence for establishing ApoE allele status over this rs445925 prediction if present.
Source and license
Adapted from rs445925(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.