rs450046

A SNP in the PRODH gene on chromosome 22. Its most notable genotype is C;C: common in clinvar

Gene
PRODH
Location
Chr 2218,913,491 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.02% of people
  2. T;TNot ratedNo summary available.Typical · 0.081% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 2% T;T 81%
  • European ancestry (Utah)C;C 0% T;T 88%
  • Han Chinese (Beijing)C;C <1% T;T 93%
  • Japanese (Tokyo)C;C 0% T;T 95%
  • Yoruba (Nigeria)C;C 5% T;T 65%
  • African ancestry (Southwest US)C;C 5% T;T 70%
  • Chinese (Denver)C;C 0% T;T 95%
  • Gujarati IndianC;C 1% T;T 86%
  • Luhya (Kenya)C;C 9% T;T 57%
  • Mexican ancestry (Los Angeles)C;C 0% T;T 86%
  • Maasai (Kenya)C;C 4% T;T 63%
  • TuscanC;C 0% T;T 89%

Conditions, medicines and genes

Other PRODH SNPs

All PRODH SNPs

Notes

From SNPedia

Show notes, about 120 words

also referred to as 1766A/G plos rs450046 was most strongly positively associated with schizophrenia in families. rs372055(C), rs450046(G), rs385440(A) haplotype carriers (n = 32) exhibited attenuated PPI + verbal memory (p < .001) as well as higher anxiety (p < .004) and schizotypy (p < .008) compared to noncarriers (n = 185) Genome bioinformatic analysis of nonsynonymous SNPs. Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"? Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. Executive function, neural circuitry, and genetic mechanisms in schizophrenia.

Source and license

Adapted from rs450046 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.