rs4504469
A SNP in the KIAA0319 gene on chromosome 6. Its most notable genotype is C;C: common
- Gene
- KIAA0319
- Location
- Chr 624,588,656 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 73% C;T 23% T;T 4%
- European ancestry (Utah)C;C 39% C;T 47% T;T 15%
- Han Chinese (Beijing)C;C 82% C;T 18% T;T 0%
- Japanese (Tokyo)C;C 72% C;T 26% T;T 2%
- Yoruba (Nigeria)C;C 98% C;T 2% T;T 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 130 words
Rs4504469, a nonsynonymous SNP in exon 4 of the KIAA0319 gene, is in a region that crops up in several independent studies as likely to associated with dyslexia. The risk allele in the Caucasian populations studied is (T). The odds ratio in a study of case:control study of ~400 Caucasians associated with rs4504469(T) is 1.51 (CI: 1.17–1.95, p = 0.002). A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. A common variant associated with dyslexia reduces expression of the KIAA0319 gene. Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.
Source and license
Adapted from rs4504469 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.