rs761100

A SNP in the KIAA0319 gene on chromosome 6. Its most notable genotype is C;C: higher risk for dyslexia

Gene
KIAA0319
Location
Chr 624,632,414 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableBadhigher risk for dyslexiaMinor · 1.053% of people
  2. A;CGoodnormal riskTypical · 0.038% of people
  3. A;AGoodnormal riskTypical · 0.09% of people

SNPedia records rs761100 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 53% A;C 38% A;A 9%
  • European ancestry (Utah)C;C 26% A;C 57% A;A 17%
  • Han Chinese (Beijing)C;C 75% A;C 24% A;A <1%
  • Japanese (Tokyo)C;C 83% A;C 16% A;A <1%
  • Yoruba (Nigeria)C;C 50% A;C 39% A;A 11%
  • African ancestry (Southwest US)C;C 51% A;C 44% A;A 5%
  • Chinese (Denver)C;C 81% A;C 18% A;A <1%
  • Gujarati IndianC;C 35% A;C 53% A;A 13%
  • Luhya (Kenya)C;C 53% A;C 42% A;A 6%
  • Mexican ancestry (Los Angeles)C;C 52% A;C 43% A;A 5%
  • Maasai (Kenya)C;C 47% A;C 40% A;A 13%
  • TuscanC;C 28% A;C 48% A;A 24%

Conditions, medicines and genes

Other KIAA0319 SNPs

All KIAA0319 SNPs

Notes

From SNPedia

Notes

The more common allele of rs761100 has been linked to increased risk for developmental dyslexia in a study of ~300 British families. While odds ratios were not reported, the significance was reported as p=0.02. Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment. Developmental Dyslexia

Source and license

Adapted from rs761100 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.