rs45438698
A SNP in the KCNA5 gene on chromosome 12. Its most notable genotype is A;A: not seen (too rare)
- Gene
- KCNA5
- Location
- Chr 125,045,880 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Notes
From SNPedia
Notes
This SNP, also known as R578K, affecting an amino acid in exon 1 of the KCNA5 potassium channel gene, may mediate the response to drugs such as quinidine and propafenone. The risk allele is rs45438698(A), and carriers receiving quinidine or propafenone for the treatment of cardiac arrhythmias may be resistant to the drug (and thus treatment). Note that this allele is rare; it was not observed in African-American or Asian populations, however it is reported to be present at a frequency of 1.1% among Caucasians.
Source and license
Adapted from rs45438698 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.