rs45477792

A SNP in the KCNA5 gene on chromosome 12. Its most notable genotype is C;C: common

Gene
KCNA5
Location
Chr 125,045,742 (GRCh38)
Highest magnitude
0.0Typical
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedcommonTypical · 0.0
  2. C;TNot ratedresistant to drug blockTypical · 0.0
  3. T;TNot ratednot seen (too rare)Typical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other KCNA5 SNPs

All KCNA5 SNPs

Notes

From SNPedia

Notes

This SNP, also known as P532L, affecting an amino acid in exon 1 of the KCNA5 potassium channel gene, may mediate the response to drugs such as quinidine. The risk allele is rs45477792(T), and carriers receiving quinidine or propafenone for the treatment of cardiac arrhythmias may be resistant to the drug (and thus treatment). Note that this allele is rare; it was not observed in Caucasian or Asian populations, however it is reported to be present at a frequency of 0.8% (i.e. less than 1%) among African-Americans.

Source and license

Adapted from rs45477792 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.