rs4570625(G;G)

Maybe: higher scores on anxiety-related personality traits; greater placebo response

Magnitude
1.5Minor
Repute
Bad
Frequency
41%Average of 11 populations
On SNPedia
rs4570625(G;G)
Gene
TPH2

Frequency

Share of people with G;G in each HapMap population.

  • European ancestry (Utah)65%
  • Gujarati Indian62%
  • Tuscan59%
  • African ancestry (Southwest US)46%
  • Mexican ancestry (Los Angeles)44%
  • Yoruba (Nigeria)37%
  • Maasai (Kenya)35%
  • Luhya (Kenya)32%
  • Japanese (Tokyo)25%
  • Han Chinese (Beijing)22%
  • Chinese (Denver)20%

Other genotypes of rs4570625

  1. G;TNot ratednormalTypical · 0.044% of people
  2. T;TNot ratednormalTypical · 0.016% of people

All about rs4570625

Notes

From SNPedia

One study of (only) 25 people shows this genotype was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms. A criticism of this study has also been published, and it has not been replicated since the original publication years ago. This SNP has been linked to several psychiatric and/or behavioral phenomena, including: *higher scores on anxiety-related personality traits *obsessive compulsive disorder *panic disorder with a possible gender-dependent effect

References

Source and license

Adapted from rs4570625(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.