rs4570625

A SNP in the TPH2 gene on chromosome 12. Its most notable genotype is G;G: maybe: higher scores on anxiety-related personality traits; greater placebo response

Gene
TPH2
Location
Chr 1271,938,143 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadmaybe: higher scores on anxiety-related personality traits; greater placebo responseMinor · 1.541% of people
  2. G;TNot ratednormalTypical · 0.044% of people
  3. T;TNot ratednormalTypical · 0.016% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 41% G;T 44% T;T 16%
  • European ancestry (Utah)G;G 65% G;T 29% T;T 6%
  • Han Chinese (Beijing)G;G 22% G;T 52% T;T 26%
  • Japanese (Tokyo)G;G 25% G;T 51% T;T 24%
  • Yoruba (Nigeria)G;G 37% G;T 49% T;T 14%
  • African ancestry (Southwest US)G;G 46% G;T 44% T;T 11%
  • Chinese (Denver)G;G 20% G;T 49% T;T 31%
  • Gujarati IndianG;G 62% G;T 32% T;T 6%
  • Luhya (Kenya)G;G 32% G;T 48% T;T 20%
  • Mexican ancestry (Los Angeles)G;G 44% G;T 47% T;T 9%
  • Maasai (Kenya)G;G 35% G;T 47% T;T 19%
  • TuscanG;G 59% G;T 32% T;T 9%

Conditions, medicines and genes

Other TPH2 SNPs

All TPH2 SNPs

Notes

From SNPedia

Show notes, about 460 words

rs4570625, also known as G-703T, is a SNP in the tryptophan hydroxylase 2 TPH2 gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including: * rs4570625 and rs4565946 linked to the pathogenesis of early-onset obsessive compulsive disorder * rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission * rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms. g2b2mh is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe not panic disorder with a possible gender-dependent effect Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Genetic variation of serotonin function and cognitive control. Tryptophan hydroxylase 2 gene and alcohol use among college students. Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. TPH2 gene variants and anxiety during alcohol detoxification outcome. Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features. Alternative splicing and extensive RNA editing of human TPH2 transcripts. Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. Pharmacogenetics of antidepressant response. Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants. Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene. Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.

G;G

One study of (only) 25 people shows this genotype was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms. A criticism of this study has also been published, and it has not been replicated since the original publication years ago. This SNP has been linked to several psychiatric and/or behavioral phenomena, including: *higher scores on anxiety-related personality traits *obsessive compulsive disorder *panic disorder with a possible gender-dependent effect

References

Source and license

Adapted from rs4570625 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.