rs4290270
A SNP in the TPH2 gene on chromosome 12. Its most notable genotype is A;A: common in clinvar
- Gene
- TPH2
- Location
- Chr 1272,022,455 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 49%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 20%
- European ancestry (Utah)A;A 11%
- Han Chinese (Beijing)A;A 22%
- Japanese (Tokyo)A;A 13%
- Yoruba (Nigeria)A;A 35%
Related
Other TPH2 SNPs
- rs120074176C;TPossible increased risk for ADHD and other psychiatric disordersVery important
- rs1843809G;Gslightly decreased risk for ADHDMinor
- rs4570625G;Gmaybe: higher scores on anxiety-related personality traits; greater placebo responseMinor
- rs1386494A;GNo summary available.Typical
- rs4565946C;CRisk of early-onset OCDTypical
- rs7305115A;AIndividuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotypeTypical
- rs11178997T;TNo summary available.Typical
- rs11615016A;ANo summary available.Typical
Notes
From SNPedia
Notes
Only for Hispanics, individuals who have a genoset composed of rs1799913(C;C) and rs4290270(T;T) are reported to be at 9x higher risk for developing heroin addiction (CI:0.83-244.63, p=0.012).
Source and license
Adapted from rs4290270 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.