rs7305115
A SNP in the TPH2 gene on chromosome 12. Its most notable genotype is A;A: Individuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype
- Gene
- TPH2
- Location
- Chr 1271,979,082 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 47%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableGoodIndividuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype
- A;GNot ratedrisk of suicide behavior
- G;GNot ratedrisk of suicide behavior
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 21% A;G 48% G;G 31%
- European ancestry (Utah)A;A 17% A;G 38% G;G 46%
- Han Chinese (Beijing)A;A 22% A;G 52% G;G 27%
- Japanese (Tokyo)A;A 20% A;G 46% G;G 34%
- Yoruba (Nigeria)A;A 12% A;G 44% G;G 44%
- African ancestry (Southwest US)A;A 11% A;G 51% G;G 39%
- Chinese (Denver)A;A 31% A;G 56% G;G 14%
- Gujarati IndianA;A 22% A;G 49% G;G 30%
- Luhya (Kenya)A;A 27% A;G 48% G;G 25%
- Mexican ancestry (Los Angeles)A;A 24% A;G 53% G;G 22%
- Maasai (Kenya)A;A 21% A;G 53% G;G 26%
- TuscanA;A 27% A;G 42% G;G 31%
Related
Conditions, medicines and genes
Other TPH2 SNPs
- rs120074176C;TPossible increased risk for ADHD and other psychiatric disordersVery important
- rs1843809G;Gslightly decreased risk for ADHDMinor
- rs4570625G;Gmaybe: higher scores on anxiety-related personality traits; greater placebo responseMinor
- rs1386494A;GNo summary available.Typical
- rs4290270A;Acommon in clinvarTypical
- rs4565946C;CRisk of early-onset OCDTypical
- rs11178997T;TNo summary available.Typical
- rs11615016A;ANo summary available.Typical
Notes
From SNPedia
Notes
Effect of rs7305115 on susceptibility to suicide.
Source and license
Adapted from rs7305115 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.