rs4565946

A SNP in the TPH2 gene on chromosome 12. Its most notable genotype is C;C: Risk of early-onset OCD

Gene
TPH2
Location
Chr 1271,942,989 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadRisk of early-onset OCDTypical · 0.054% of people
  2. C;TNot ratedNo summary available.Typical · 0.036% of people
  3. T;TNot ratedNo summary available.Typical · 0.09% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 54% C;T 36% T;T 9%
  • European ancestry (Utah)C;C 27% C;T 45% T;T 28%
  • Han Chinese (Beijing)C;C 48% C;T 46% T;T 6%
  • Japanese (Tokyo)C;C 43% C;T 45% T;T 12%
  • Yoruba (Nigeria)C;C 84% C;T 15% T;T <1%
  • African ancestry (Southwest US)C;C 77% C;T 18% T;T 5%
  • Chinese (Denver)C;C 53% C;T 40% T;T 6%
  • Gujarati IndianC;C 40% C;T 47% T;T 14%
  • Luhya (Kenya)C;C 78% C;T 20% T;T 2%
  • Mexican ancestry (Los Angeles)C;C 50% C;T 47% T;T 3%
  • Maasai (Kenya)C;C 63% C;T 34% T;T 3%
  • TuscanC;C 34% C;T 43% T;T 24%

Conditions, medicines and genes

Other TPH2 SNPs

All TPH2 SNPs

Notes

From SNPedia

Notes

rs4570625 and rs4565946 linked to the pathogenesis of early-onset obsessive compulsive disorder Tourette's Syndrome

Source and license

Adapted from rs4565946 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.