rs11178997
A SNP in the TPH2 gene on chromosome 12. Its most notable genotype is T;T.
- Gene
- TPH2
- Location
- Chr 1271,938,373 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 14%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TPH2 SNPs
- rs120074176C;TPossible increased risk for ADHD and other psychiatric disordersVery important
- rs1843809G;Gslightly decreased risk for ADHDMinor
- rs4570625G;Gmaybe: higher scores on anxiety-related personality traits; greater placebo responseMinor
- rs1386494A;GNo summary available.Typical
- rs4290270A;Acommon in clinvarTypical
- rs4565946C;CRisk of early-onset OCDTypical
- rs7305115A;AIndividuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotypeTypical
- rs11615016A;ANo summary available.Typical
Notes
From SNPedia
Show notes, about 240 words
rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission paper Association with and bipolar disorder in a Northern Swedish, Isolated Population. 182 patients and 364 unrelated control individuals. P = .001 rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain. paper Carriers of the A-Allele of rs11178997 showed a decreased cortisol and ACTH stimulation. might be crucial factors for major depression pdf paper associated with bipolar disorder Minor allele yielded odds ratio of 1.5 (CI:1.2-1.9) for increased risk for bipolar disorder in a study of 883 Russian patients. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. Tryptophan hydroxylase 2 gene and alcohol use among college students. Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population. Alternative splicing and extensive RNA editing of human TPH2 transcripts. Pharmacogenetics of antidepressant response. Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.
T;T
common for Caucasians on the 23andme platform
Source and license
Adapted from rs11178997 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.