rs4665058

A SNP in the BAZ2B gene on chromosome 2. Its most notable genotype is A;A: ~4x increased risk among Europeans for sudden cardiac death

Gene
BAZ2B
Location
Chr 2159,333,698 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad~4x increased risk among Europeans for sudden cardiac deathWorth knowing · 2.16% of people
  2. A;CBad2x increased risk among Europeans for sudden cardiac deathWorth knowing · 2.021% of people
  3. C;CGoodcommon in complete genomicsTypical · 0.074% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 6% A;C 21% C;C 74%
  • European ancestry (Utah)A;A 0% A;C 6% C;C 94%
  • Han Chinese (Beijing)A;A 2% A;C 20% C;C 78%
  • Japanese (Tokyo)A;A 2% A;C 18% C;C 80%
  • Yoruba (Nigeria)A;A 18% A;C 40% C;C 43%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs4665058 is a SNP in the bromodomain adjacent zinc finger domain 2B BAZ2B locus on ch 2q24.2. A GWAS meta-analysis in 1,283 cases of sudden cardiac death (SCD; presumably from myocardial infarction) and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in 3,000+ cases, associated rs4665058 with SCD risk (p = 1.8×10e?10). The per allele odds ratio for the risk allele, rs4665058(A), is 1.92 (CI: 1.57–2.34).

A;A

Only a single study, a long time ago, with no replication.

A;C

Only 1 publication, a long time ago, with no replication

Source and license

Adapted from rs4665058 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.