rs4680(A;A)

(worrier) advantage in memory and attention tasks

Magnitude
2.5Worth knowing
Repute
Good
Frequency
13%Average of 11 populations
On SNPedia
rs4680(A;A)
Gene
COMT

Frequency

Share of people with A;A in each HapMap population.

  • European ancestry (Utah)25%
  • Gujarati Indian22%
  • Tuscan20%
  • Mexican ancestry (Los Angeles)14%
  • African ancestry (Southwest US)12%
  • Han Chinese (Beijing)10%
  • Yoruba (Nigeria)10%
  • Maasai (Kenya)8%
  • Luhya (Kenya)8%
  • Japanese (Tokyo)6%
  • Chinese (Denver)5%

Other genotypes of rs4680

  1. A;GNot ratedIntermediate dopamine levels, other effectsTypical · 0.042% of people
  2. G;GGood(warrior) multiple associations, see detailsWorth knowing · 2.545% of people

All about rs4680

Notes

From SNPedia

Little or no response to modafinil. You are more difficult to hypnotise. Placebo is more effective http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?ref=magazine&pagewanted=all

References

Source and license

Adapted from rs4680(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.